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Postdoc to Study Gene Regulatory Mechanisms Involved in Human Diabetes

IDIBAPS - August Pi i Sunyer Biomedical Research Institute

Barcelona, Spain

The Beta Cell Genome Regulation lab (IDIBAPS) seeks a talented and enthusiastic candidate for a postdoctoral position to study gene regulatory mechanisms in human diabetes.

The successful candidate will lead a project focused on understanding epigenetic mechanisms in pancreatic beta cells relevant to the pathogenesis of human disease. Two projects are available to achieve this, including studying an existing unpublished mouse genetic model that has been generated by the team, and deploying CRISPR-Cas9 methods implemented in the lab to engineer epigenetic and genetic alteration in human cell lines. It is also possible for the postdoctoral scientist to propose new projects that are aligned with the lab’s interests, as well as engaging in collaborative projects with other lab members.

The host lab interests include:

  • Non-coding genome function in development and disease (see Weedon et al, Nature Genetics 2014, Pasquali et al, Nature Genetics 2014, Cebola et al Nat Cell Biol 2015),
  • Long non-coding RNAs (Moran et al, Cell Metab 2012, Akerman et al, Cell Metab 2016)
  • Developmental programming of pancreatic lineages (van Arensbergen et al, Genome Res 2010 and Genes and Dev, 2013; Solar et al, Dev Cell 2009).

The team is led by Jorge Ferrer, and is highly multidisciplinary, with members that have expertise in computational biology, chromatin biology, developmental biology and genetics. The successful candidate will work lab members in Esther Koplowitz institute, IDIBAPS as well as with colleagues in Imperial College which interact in regular teleconference meetings and frequent interchanges. The successful candidate will have a chance to interact with several consortia in which the team participates actively, including ZENCODE, T2DSYSTEMS, HIRN, a collaborative project funded by MaratoTV3, and CHROME.

The successful candidate is expected to have completed a PhD, and have at least one publication as leading author in peer-reviewed journals focused on either mouse genetic analysis, genome regulation or chromatin biology. Other relevant backgrounds will be considered.

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