Postdoctoral Fellow - German Consortium for Translational Cancer Research (DKTK)
DKFZ - German Cancer Research Center
We encourage a highly motivated and qualified candidate to apply for a postdoctoral position in the department of "Oncogenic signaling pathways of colorectal/pancreatic cancer" at the DKTK partner site located at the Institute of Pathology, Ludwig-Maximilians-University Munich (LMU). The project aims to study the effect of chromosomal instability (CIN) and aneuploidy at early stages of colorectal cancer development and cancer progression. In this context, the secretory activity of chromosomally stable and instable primary human adenoma and tumor organoids generated by CRISPR/Cas9-mediated genome editing will be addressed. The goal will be to decipher the activation state of cellular stress pathways, their impact on the tumor secretome, and the resulting effect on the adjacent microenvironment. The successful candidate will work at the interface between molecular oncology and medical science, will apply 2D/3D tissue-culture techniques, and the project includes work with primary patient material. Experience will be also gained in proteomics and next generation sequencing techniques and data processing. Funding has been granted for this project by the german research foundation (DFG).
Ideally, you are experienced in 3-D organoid culture systems, CRISPR/Cas9-mediated genome editing, and signaling pathway analyses. Required are also skills in molecular biology, confocal microscopy, flow cytometry, and proteome/secretome analysis. Experience with scientific data analyses (bioinformatics and biostatistics) and data mining of cancer genomic databases (e.g. TCGA) we see as an important asset. You should hold a Ph.D. degree in the area of life sciences with an excellent background in biology/tumor biology. We prefer a candidate with strong laboratory, analytical, and communication skills. You should be enthusiastic about cancer research, self-motivated, result-driven, reliable, and have a critical personality. Required are good organization, German/English writing and communication skills, and the ability to work efficiently both on an individual research project and in a team environment.
The Translation Centre is located in the premises of the Ludwig-Maximilians-University Munich (LMU).