Post-doctoral Position in Infection Biology
A one-year post-doctoral position is available at the Cochin Institute in Paris to study the signaling pathways controlling inflammation during infection by enteroinvasive bacteria.
Intestinal epithelial cells play a critical role in innate immunity. They can detect the presence of invasive bacteria and contribute, with macrophages, to the secretion of factors that orchestrate inflammation and limit bacterial dissemination in infected tissues. In this context, our laboratory discovered a gap junction-mediated mechanism of cell-cell communication that potentiates the innate immune response of epithelial cells during infection by enteroinvasive bacteria such as Shigella flexneri, Listeria monocytogenes and Salmonella typhimurium (Kasper et al. Immunity, 2010). Using a genome wide RNAi approach, we recently identified several proteins involved in this process and showed that they are broadly involved in the control of cytokine expression after infection by gram-negative bacteria (manuscript under review). The goal of the project will be to use biochemistry, proteomics and imaging to characterize the roles of these proteins in the control of innate immunity during bacterial infection.
We are looking for a highly motivated candidate with strong expertise in cell biology, biochemistry and proteomics.