Postdoc Position to Study Human Immune Responses to Viral Infection Using Novel ‘Humanized’ Mouse Models
The Innate Immunity Unit is recruiting postdoctoral fellows to study human immunity to viral pathogens (HIV, HBV, CMV) using innovative ‘human immune system’ (HIS) mice. We have recently created novel Balb/c Rag2 Il2rg SirpaNOD (BRGS) mouse strains with enhanced human DC and ILC generation, expression of human HLA class I and class II transgenes and normal LN development. These optimized BRGS recipients show vastly improved antigen-specific cellular and humoral human immune responses after immunization and/or infection.
We are using these latest generation HIS mice to explore:
- Role for NK cell expressed FcR in human ADCC and bNAb function in the context of HIV infection;
- Cross-talk between ILC and T cells in anti-viral responses to HCMV and HBV;
- Combination immunotherapy for HIV and HBV ‘cure’.