The project is focused on the therapeutic potential of CRISPR/Cas9 in correcting genetic diseases of the hematopoietic system. The project aims to address current bottlenecks in the methodology for applying the system to a wide range of hematopoietic disorders. The candidate will work on improving various aspects of existing techniques as well as developing novel approaches for in vivo delivery of gene editing components.
We seek a highly motivated candidate with a solid background in genetics, hematology and/or immunology. Expertise in standard molecular biology techniques and cell culture is critical, and experience with plasmid cloning, gene editing, AAV vector production, FACS, and mouse handling is highly desirable. The candidate is required to have strong skills in English and proven abilities to publish at a high international level with at least one first author publication. Motivation to work independently and be responsible for the daily management of his/her research project in coordination with other members of the group is expected. The candidate will also be actively involved in the training and co-supervision of other group members and students.