Scientist for the Development of Antiinfective Drug Molecules

Scientist for the Development of Antiinfective Drug Molecules

TUM - Technical University Munich

Munich, Germany

Our profile

The group of Dr. Meyer at the Institut für Medizinische Mikrobiologie, Immunologie und Hygiene at the Technische Universität München is dedicated to developing innovative treatment options to meet the increasing threat by antibiotic resistances. In particular gram-negative, carbapenem-resistant infections pose a massive clinical challenge as there are very few - if any - treatment options left. We have identified two innovative molecule classes, which open novel therapeutic prospects. Within a BMBF funded project, we aim to further develop both compound classes in collaboration with two Helm-holtz Institutes in Neuherberg (structure analysis) and Braunschweig (medicinal chemistry). The focus of this project is the pathogen-targeted optimization of the compounds with respect to pathogen species, expressed antibiotic resistances, and other resistance enhancing mechanisms.

Your profile

  • University degree in Biology, Biochemistry, Molecular Biotechnology, Pharmacy or comparable subjects with PhD degree;
  • Experience in handling pathogenic bacteria;
  • Expertise in antibiotic resistance mechanisms;
  • Experience in mass spectrometry and HPLC is a plus;
  • Experience in non- and pre-clinical drug development (preferably in a pharma setting);
  • Accurate, diligent and reliable conduction of lab work;
  • Enthusiasm for translational science;
  • Excellent team spirit and communication skills.

Your tasks

  • Establish a collection of gram-negative clinical isolates;
  • Characterization of the bacteria with respect to antibiotic resistances and resistance-enhancing features;
  • Whole genome sequencing of the bacterial genomes;
  • Activity testing of inhibitory compounds in bacterial growth assays;
  • Establishing mass spectrometry based resistance assays;
  • Support in a first ADME/Tox profiling of inhibitors.

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TUM - Technical University Munich     Germany     Academic     Biology     Biotechnology and Genetics     Chemistry     Microbiology     PhD Required     Pharmaceutical    

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