This is an exciting opportunity to join a new team developing gene drive systems in mosquitoes, specifically the “daisy drive” concept for locally-acting, safe, reversible gene drive systems. No daisy drive has yet been developed. We aim to extend the current state of the art by engineering such systems, taking a synthetic biology approach. Several related designs share various components, e.g. RNA-guided nucleases such as CRISPR/Cas9, and will be developed in parallel. This is an iterative approach guided by mathematical models; conversely the models will be continuously refined by incorporating empirical data as it becomes available. This is part of an international project that will develop daisy drive components and systems in several species including nematodes and mosquitoes, addressing ethical and legal issues, for example, as well as technical ones. The Pirbright component will focus on mosquitoes, specifically aedes aegypti, the primary vector of dengue, chikungunya and yellow fever viruses and Culex quinquefasciatus, the key vector of avian malaria in Hawaii and a vector of West Nile virus and filariasis elsewhere.