Protein Crystallography Facility Manager - Structural Studies - Dr David Barford

Protein Crystallography Facility Manager - Structural Studies - Dr David Barford

MRC Laboratory of Molecular Biology

Cambridge, United Kingdom

Job Description

Overall purpose:

  • To play a major role in supporting the work of the research of groups in the Laboratory of Molecular Biology (LMB) by leading the Protein Crystallography facility, carrying out X-ray crystal structure determinations and providing expert help and support.
  • To optimise the effectiveness of both in-house and synchrotron X-ray data collection.
  • To provide training to new X-ray users, troubleshooting problems in data collection and to maintain the in-house data collection facilities and software setup.
  • To collaborate with research groups to determine crystal structures and participate in structure analysis.
  • To oversee safety procedures in the X-ray laboratory.
  • To keep abreast of new developments in protein crystallographic technologies and methods and assess and advise on any future upgrades of the in-house X-ray facility.

Main duties and key responsibilities:

  • The key responsibility is to support cutting edge research. You will be expected to provide the intellectual energy and independent thinking necessary to deliver an optimally functioning X-ray facility and to play a major role in shaping the overall aims and success of the structural objectives of the LMB.
  • To provide expert help and advice to all researchers in the institute solving structures by X-ray crystallography, requiring or requesting such support. To provide expert help to researchers during structure determination by X-ray crystallography, when required, and often in collaboration with the groups performing the work.
  • To interact effectively with a wide range of staff, students and others to ensure the smooth running of the X-ray facility. This will include setting an example in the effective use of resources, training Students, Postdocs and others in best practice when using both the in-house facility and in collecting data at synchrotrons and taking responsibility for the use of communal facilities.
  • To be responsible for all aspects of supporting X-ray crystallographic data collection, including defining the goals of the facility, conducting trouble-shooting when necessary, carrying out routine maintenance of the facility and evaluating possible equipment upgrades. To arrange and facilitate engineers visits when required.
  • To maintain familiarity with the hardware in use at the crystallographic beamlines at Diamond Light Source (DLS) and the European Synchrotron Radiation Facility (ESRF) and other synchrotrons as required. To maintain familiarity with the software for both data processing and structure solution pipelines available at DLS and ESRF and other synchrotrons as required.
  • To play a major role in the organisation of the use of synchrotron beamtime, ensuring all necessary administrative procedures are followed, including sample registration, dewar shipping and, if required, accommodation.
  • To take on specific responsibilities for managing equipment.
  • To update local software installations relating to X-ray crystallography and related areas.
  • To create and maintain documentation relating to use of the facility and synchrotron data collection.
  • To maintain documents relevant to X-ray safety (Local Rules etc) and operate as the Radiation Protection Supervisor for the facility.
  • To act as the coordinator for the LMB Diamond Block Allocation Group (BAG), having responsibility for renewing the BAG and submitting reports on beam-time use and outputs (papers and PDB depositions).
  • To contribute to the MRC’s engagement with the public and in the translation of research findings into improvements in health care.

Working relationships:

You will report to Dr David Barford.

You will work with members of the Mechanical Workshop who will assist in some aspects of maintenance of the facility (eg X-ray generator filament replacement, vacuum systems, cryo-cooling systems) and with members of the Instrument Services, IT workshop and Electronics Workshop as required. You will also liaise with other Group Leaders, Research Support staff, Post-doctoral scientists and Students across the LMB.

Additional information:

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC.

The position will require some travel to synchrotrons both in the UK and abroad, and will involve working outside normal working hours, including at weekends.

Person Specification

Education/qualifications/training required:

Essential:

  • Either a PhD in biology, engineering, physics, materials sciences or a related subject or an equivalent level of experience or training in a relevant area.

Previous work experience required:

Essential:

  • Extensive experience in biological crystal structure determination by all common methods.
  • Extensive experience of X-ray data collection using both laboratory and synchrotron sources.
  • Experience of dealing with technical problems with in-house X-ray generators, X-ray optics and detectors.
  • Experience of organisation of synchrotron data collection trips.
  • Experience of and ability to provide training to a wide range of users.
  • Experience of using crystallographic software packages such as CCP4 or Phenix.

Desirable:

  • Experience of using data processing and structure solution pipelines at synchrotron sources.
  • Experience of providing research support in a laboratory environment.
  • Programming experience.

Knowledge and experience:

Creativity and initiative

Essential:

  • Experience working independently in a creative and insightful way to trouble-shoot complex problems.

Independent working

Essential:

  • Ability to work independently in maintaining the facility, while making use of other facilities (mechanical and electronic workshops, IT workshop) when appropriate.
  • Ability to devise written protocols and provide reports on the facility.
  • Excellent time management, with an ability to be self-motivated and to organise time effectively.

Desirable:

  • Ability to provide assistance with structure solutions.
  • Verbal and written communication skills

Essential:

  • Excellent interpersonal skills with the ability to communicate at all levels of technical complexity with novice and advanced users, as well as experts including service engineers.
  • Ability to provide clear documentation of protocols and written reports.

Personal skills/behaviours/qualities:

Essential:

  • Excellent standards of professional conduct.

Apply Now

Don't forget to mention EuroScienceJobs when applying.

Share this Job

More Job Searches

MRC Laboratory of Molecular Biology     United Kingdom     Biochemistry     Biology     Engineering     Government/Public Sector     PhD Required     Physics     Solid State Physics    

© EuroJobsites 2018

EuroJobsites is a UK registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

Newsletter | Recruit | Advertise | Privacy | Contact Us

© EuroJobsites 2018

EuroJobsites is a UK registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

This website uses cookies to make your experience better. Continued use of this website means you accept our cookie policy.  Accept Cookies