Our main research question is to understand how L. pneumophila subverts host functions to replicate in the host cell and to cause disease. A specific question in this context is how does L. pneumophila target the host cell nucleus to change the cellular response.
We have described an effector (RomA) that marks histones to down regulate the host response during infection (Rolando, M. et al. Cell Host Microbe 13, 395–405 (2013)).
Recently, our in-depth search for additional putative chromatin modifying effectors led to the identification of five such proteins.
The successful candidate will be involved in the characterization of the chromatin signature of L. pneumophila during infection by analyzing the activities of the secreted nucleomodulines
The ideal candidate would have experience in cell biology, biochemistry and chromatin analyses.
Excellent written and oral communication skills and proficiency in English are required. French is optional.
The candidate should have good interpersonal skills and ability to work independently, but also to interact well within a research group.
The candidate is expected independently establish all necessary techniques and introduce new technologies.
The work will be performed under the supervision of Dr. Monica Rolando.