Post-doctoral Position: Deciphering Legionella Pneumophila Induced Epigenetic Modifications

Post-doctoral Position: Deciphering Legionella Pneumophila Induced Epigenetic Modifications

Institut Pasteur

Paris, France

Project:

  • Our main research question is to understand how L. pneumophila subverts host functions to replicate in the host cell and to cause disease. A specific question in this context is how does L. pneumophila target the host cell nucleus to change the cellular response.
  • We have described an effector (RomA) that marks histones to down regulate the host response during infection (Rolando, M. et al. Cell Host Microbe 13, 395–405 (2013)).
  • Recently, our in-depth search for additional putative chromatin modifying effectors led to the identification of five such proteins.
  • The successful candidate will be involved in the characterization of the chromatin signature of L. pneumophila during infection by analyzing the activities of the secreted nucleomodulines

Requirements:

  • The ideal candidate would have experience in cell biology, biochemistry and chromatin analyses.
  • Excellent written and oral communication skills and proficiency in English are required. French is optional.
  • The candidate should have good interpersonal skills and ability to work independently, but also to interact well within a research group.
  • The candidate is expected independently establish all necessary techniques and introduce new technologies.
  • The work will be performed under the supervision of Dr. Monica Rolando.

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EuroJobsites is a UK registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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