The Institute of Laboratory Animal Science, group of Prof. Buch, offers a postdoctoral position (2 years) with a focus on T-cell development.
The group is working on how T-cell tolerance is built up and how and why it is broken in autoimmune diseases.
During T-cell development there is a first important checkpoint, negative selection, which is important for tolerance induction. To investigate and to gain a deeper understanding of this process, new mouse models (conditional as well as crispered mice) will be used in the project. In addition, a series of studies will be undertaken on cell lines which show negative selection. During the project not only basic immunological methods but also high parameter assays (Cytof, Symphony, RNAseq) and the latest screening methods (CRISPR/Cas9-based) can be applied. The models and methods are established, and primary data support the entry into the project. The project can and should develop with the interests of the postdoctoral fellow.