Postdoc in T-cell Development

Postdoc in T-cell Development

University of Zurich

Zurich, Switzerland

Description of UZH unit

The Institute of Laboratory Animal Science, group of Prof. Buch, offers a postdoctoral position (2 years) with a focus on T-cell development.

The group is working on how T-cell tolerance is built up and how and why it is broken in autoimmune diseases.

Responsibilities

The project

During T-cell development there is a first important checkpoint, negative selection, which is important for tolerance induction. To investigate and to gain a deeper understanding of this process, new mouse models (conditional as well as crispered mice) will be used in the project. In addition, a series of studies will be undertaken on cell lines which show negative selection. During the project not only basic immunological methods but also high parameter assays (Cytof, Symphony, RNAseq) and the latest screening methods (CRISPR/Cas9-based) can be applied. The models and methods are established, and primary data support the entry into the project. The project can and should develop with the interests of the postdoctoral fellow.

Workload in %

  • 100 %.

Qualifications

Profile of postdoctoral student

  • Degree and doctorate in biology, biochemistry, biomedicine, medicine or equivalent with an immunological focus;
  • Deep immunological understanding and interest in T cells;
  • Experience in flow cytometry, cell culture and molecular biology;
  • Experience in work with animals;
  • Ability to work independently.

Language requirements

  • Good English skills

Computer skills

  • Good computer skills.

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EuroJobsites is a UK registered company number: 4694396 VAT number: GB 880 9055 04

Registered address: EuroJobsites Ltd, Unit 8, Kingsmill Business Park, Kingston Upon Thames, London, KT1 3GZ, United Kingdom

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