At the VIB-VUB Center for Structural Biology (Vrije Universiteit Brussel/VIB), we are looking for a highly qualified and motivated postdoctoral researcher with a strong background in Cryo-EM and/or X-ray crystallography, biochemistry and biophysics, and interested in biochemical and structural studies on complex multi-domain GTPases implicated in human disease.
Roco proteins form a class of large multi-domain GTPases that are regulated via complex and still largely unresolved mechanisms. Mutations in the genes coding for human Roco proteins lead to cancer and devastating neurological disorders such as Parkinson’s disease.
The Versées lab aims to unravel the mechanisms and regulatory pathways that underlie the function and dysfunction of different representatives of bacterial and human Roco proteins (e.g. Deyaert et al. Nat.Commun. 2017, Guaitoli et al. PNAS 2016). In this project you will use single particle cryo-EM and X-ray crystallography, in combination with biophysical methods and enzyme kinetics, to gain insight in the conformational cycle of Roco proteins. This information will subsequently be used to intervene with this cycle to devise new potential therapeutic strategies.