A postdoctoral research position is immediately available for structure-function studies of proteins involved in redox metabolite signaling. Successful candidates will join the exciting research environment of the Messens laboratory at the VIB-VUB Center for Structural Biology in Brussels, Belgium.
The Messens laboratory is recognized as a world leader in the redox field, and the lab provides an outstanding position in protein biochemistry and structural biology, in a highly dynamic and team-oriented research group. In this cutting-edge research environment, you will tackle essential biological problems in metabolite signaling.
We decipher how cells sense redox metabolites and transduce stimuli into downstream biological effects. Knowledge of the mechanisms by which sensors and transducers function are invaluable in understanding how redox homeostasis pathways can be engineered with the ultimate goal of improving oxidative stress resistance in plants and to identifying therapeutic targets in diseases such as diabetes and cancer, which have been associated with aberrant redox signaling.
You will be involved in a project that exploits prokaryotic proteins for the de novo design of biosensors with a fluorescent read-out for both in vitro studies and live imaging of cellular metabolic changes. Further, your expertise will be needed for the structural and functional analysis of plant H2O2-sensing proteins to understand how organelle communication functions at the molecular level.