A postdoctoral position is available in the group of Prof. Patrick Matthias at the Friedrich Miescher Institute for Biomedical Research (FMI), in Basel-Switzerland, to study the role of Histone deacetylases (HDACs) in chromatin regulation B cell development.
Our laboratory has a long-standing interest in understanding the biological roles of Histone Deacetylases (HDACs; e.g. Kwon et al., G&D, 2007; Zhang et al., MCB 2008; Yamaguchi et al., G&D 2010; Jacob et al., Nat Neurosci 2011; Miyake et al., Nat. Chem. Biol. 2016; Pillonel et al., Sci. Rep. 2016). Based on our recent unpublished results, we aim at understanding how class I HDACs interplay with transcription factors and contribute to essential aspects of B cell development and function, such as immunoglobulin gene rearrangement and related processes. Additional projects in this area interrogate the role of transcription factors for enhancer establishment in B cells. These projects use a wide range of technologies, from genomics to CRISPR-edited mice.
The successful candidate should have a recent PhD with expertise in chromatin analysis approaches (e.g. ChIP-seq, ATAC-Seq, RNA-seq,…), as well as some experience in analysis of lymphoid development (FACS analysis, in vitro culture,…). Ability to analyze genomic data is an advantage. Candidates should have a demonstrated publication record -with at least 1 first author paper published or in press-, be highly self-motivated and work well in a team or as an individual contributor. Excellent communication and organization skills are expected. A very competitive salary and access to world-class state-of-the-art research facilities will be provided.