The main goal of the research group “Molecular Neuropathology of Neurodegenerative Diseases” (Prof. Dr. Manuela Neumann) is to understand the molecular mechanisms underlying frontotemporal dementia and amyotrophic lateral sclerosis, with specific emphasis on the role of TDP-43, FET proteins and C9orf72 in the pathogenesis.
The specific focus of the project will be on the identification of posttranslational modifications of TDP-43 and FET proteins and characterization of their functional consequences with respect to the normal function of these proteins and their role in the disease pathogenesis. Identified modifications will also be tested for suitability as biomarker and drug target. Primary methods will include different protein purification methods, biochemical separation techniques, mass spectrometry and cell culture.
Applicants must have a Ph.D. and should have a strong background in protein biochemistry and molecular biology. Prior experiences in protein research and biochemical analytics are highly desirable. Applicants should be fluent in English and possess good communication and team working skills.