Post-doctoral Position in Heart Morphogenesis
Post-doctoral Position in Heart Morphogenesis
Institut Pasteur
Paris, France
Post-doctoral position available to study the mechanisms of left-right asymmetry and clinical relevance to congenital heart defects.
The heart functions in two parallel but asymmetric circuits, in which the right and left ventricles drive the pulmonary and systemic circulations, respectively. In the heterotaxy syndrome, abnormal left-right patterning of the embryo leads to a spectrum of severe structural heart defects, the heterogeneity of which remains puzzling. Whereas the molecular cascade breaking the bilateral symmetry of the early embryo has been well characterised, how asymmetry is sensed by organ-specific precursor cells to control organogenesis remains poorly understood.
The Meilhac lab uses mouse as a model to elucidate basic mechanisms of asymmetric heart morphogenesis, uncover novel genetic players and explore how this relates to congenital heart defects in patients.
Previous work in the lab has characterized mouse models of heterotaxy and generated a large transcriptomic dataset to screen for novel asymmetric factors. A challenge is to understand their function at specific asymmetric steps of heart morphogenesis. The project will exploit interdisciplinary expertise at the forefront of developmental biology, computational science 3D imaging, the project will provide novel insins ines in mins, mouseen is and unani wahil deciphering pathological processes in the heart, potentially relevant to other asymmetric visceral organs.
Expected profile
After a PhD in Life Sciences, you have a strong interest in developmental biology. Your previous research experience is solid in molecular biology or genetics. You value animal models. You work with rigour and creativity and enjoy team work.
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