Postdoc in the Calmodulinopathy Research Program
Postdoc in the Calmodulinopathy Research Program
Aalborg University
Aalborg, Denmark
Job description:
Calmodulinopathies were first described, when we in 2012 first coupled human genetic variants in calmodulin to cardiac arrhythmia. Since then, a major research focus for us has been to understand the molecular consequences of these variants on protein structure and function, on calmodulin’s interaction with other proteins, and how this translates to disease phenotype. To this end, we have implemented several advanced biophysical assays to measure effects on protein interactions. Today, we are a meta-group of complementing research fields, where we study calmodulin variants across genetics, protein structure, protein biophysics, cell biology and inC. elegans model animals.
In this postdoc position, you will study effects of calmodulin variants in model systems based on cultured cells. There are two major components of the project: First you will study calmodulin’s regulation of other proteins in immortalized cell lines, such as HEK and SH-SY5Y. This includes studying the regulation of the calcium channel ryanodine receptor type 2. There will be a focus on microscopy-based methods, and you will participate in designing and/or implementing new assays. The second part of the project focuses on the effects of calmodulin variants on cardiomyocytes differentiated from patient-derived induced pluripotent stem cells. This research is currently based in Milan, and you will participate in the project there and implement some of the technology at our research facilities in Aalborg.
The project is headed by Professor Michael Toft Overgaard and Assistant Professor Helene Halkjær Jensen.
Qualification requirements:
Appointment as postdoc presupposes scientific qualifications at PhD level or similar scientific qualifications. It is a significant advantage if you have experience and qualifications in cell biology or in a closely related field. The applicant must be experienced in mammalian cell culture with a documented track-record related to these competencies. Experience with microscopy, electrophysiology, induced pluripotent stem cells, biophysical methods, or calcium signaling are considered a great advantage.
The applicant must be highly motivated and able to work systematically and independently, using problem-solving skills and critical thinking, in an interdisciplinary research environment. Excellent oral and written English language skills are a requirement, as well as a cooperative personality and good communication skills. The research potential of each applicant will be emphasized in the overall assessment. Appointment as a postdoc cannot exceed a period of four years in total at Aalborg University.
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