Postdoc - Human Milk Oligosaccharides (HMOs)
Postdoc
Hubrecht Institute
Utrecht, Netherlands
Project description:
Non-communicable diseases (NCDs) like obesity, type II diabetes, and cardiovascular disease account for almost 70% of global deaths annually. Important components in most of these conditions are intestinal perturbations and immune dysregulation or a diminished function of the immune system.
Human Milk Oligosaccharides (HMOs), a group of complex sugar structures in human milk, have various benefits in human physiology, from prebiotics to inhibitors of pathogen adherence and protection. However, it is not yet known through which cellular pathways or mechanisms HMOs exert these effects and if some HMOs are more potent than others. The aim of this project, funded by Topsector Agri&Food, is to delineate the mechanisms and effects of HMOs on the immune system and the intestinal epithelium.
The participating organizations are Radboud UMC, Radboud University, Friesland Campina and Hubrecht Institute. The Postdoc at the Hubrecht Institute will test different HMOs on intestinal organoids (mini-organs in a dish) to investigate the HMO-affected intestinal cell types and their biological mode of action.
Requirements:
We are looking for outstanding and highly motivated PostDocs with:
- A good understanding of molecular and cell biology;
- Ability to work independently but also as part of a team;
- Someone with an independent attitude to problem-solving who takes initiative;
- Proficient in molecular biology techniques and experience with culturing Organoids;
- The working language in our international teams is English; the candidate should, therefore, have excellent English communication skills.
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