Research Assistant/Associate - Pluripotent Stem Cells
Research Assistant/Associate - Pluripotent Stem Cells
Newcastle University
Newcastle, United Kingdom
Key Accountabilities
- Generate human pluripotent stem cells from patient cells that carry mtDNA mutations
- Perform differentiation of pluripotent stem cells to neurons and other relevant cell types
- Assess mtDNA mutation levels and mitochondrial function in pluripotent stem cells and derived neurons
- Perform immunofluorescence and electrophysiology to assess function of derived neurons
- Lead the experimental planning and co-ordination of above assays
- Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
- Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
- Determine appropriate methodologies for research, with advice and support where required
- Contribute to grant applications submitted by others and in time develop own research objectives and proposals for funding
- Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
- Assess research findings for the need/scope for further investigations
- Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
- Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
- May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
- Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute
- May contribute to events celebrating the public engagement of science/social sciences/humanities
- Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
The Person
Knowledge, Skills and Experience
Essential
- Experience in CRISPR/Cas9 gene editing
- Experience in differentiation of pluripotent stem cells
- Experience of tissue processing and immunofluorescence assays
- Ability to work well as part of a team and rapidly acquire new skills
- Detailed subject knowledge of stem cell biology
- Likelihood of advanced skills directly related to the research projects
- High level of analytical and problem-solving capability
- Ability to communicate complex information with clarity and to encourage the commitment of others
- Experience of research with clear transferable skills and some experience or awareness of the research environment
- Presentations at conferences and/or high-quality publications
Desirable
- Experience in assays of mitochondrial function
- Experience in single cell genomics
- Experience in assessing neuronal function
Attributes and Behaviours
Essential
- Excellent interpersonal skills including the ability to communicate clearly and concisely in writing and verbally
- Excellent organisational and time management skills
- An ability to work to deadlines, organise own workload and work independently
- Attention to detail
- A positive and supportive attitude; ability to work flexibly and cooperatively with others
Desirable
- Flexibility with respect to working hours
- Willingness to travel internationally, if required
Qualifications
- Good honours degree (or equivalent) with some subject knowledge in the relevant area (Research Assistant)
- A PhD in the research area required (Research Associate)
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