Nonclinical Drug Development (Senior) Scientist
Nonclinical Drug Development (Senior) Scientist
ProQR Therapeutics
Leiden, Netherlands
ProQR is currently recruiting a Nonclinical Drug Development Expert (Scientist/ Senior Scientist) with expertise in Toxicology and ADME to join the Translational Development team, that works in a highly collaborative fashion in Discovery and Clinical Development on in vivo pharmacology studies, in vitro and in vivo safety studies, bioanalysis, pharmacokinetics and biomarkers. In your role, you will be reporting to the VP Toxicology and DMPK / Head Preclinical Team.
The role:
ProQR is looking for an allround nonclinical subject matter expert who will be responsible for the design and monitoring in vivo studies (through selected vendors), evaluation of data, and development of PKPD/disease models in our research and development programs. Studies will range from pharmacology to toxicology (ICH/GLP). The successful candidate is an enthusiastic and creative team player and will work closely with other colleagues in an interdisciplinary team environment to progress the translational science in ProQR’s programs.
The activities include:
- Work with the project teams to develop nonclinical packages that support progression of candidates from lead selection to the clinic
- Plan, execute and oversee the conduct of external studies (including GLP studies) according to agreed timelines. Including deriving cost estimates and requesting slots at contract research organizations (CROs).
- Review of protocols and study reports, with a keen eye on data analysis and interpretation
- Generate PK, PD and safety datasets
- Integrated data analysis across studies and multiple disciplines
- Ensure timeline and budget compliance
Required qualifications:
- Typically the candidate will have at least PhD or equivalent an MSc with 5 years of experience in a relevant field.
- Knowledge and experience in pharmacology, ADME and/or Toxicology in drug development is essential
- Experience with contributions to regulatory documents and/or working with PK software is preferred
- Experience with RNA therapeutics or other innovative technologies in drug development is preferred
- Team player, with a hands-on and can-do mentality,
- Flexible attitude, being able to work in a fast pace and dynamic environment
- Pro-active and pragmatic self-starter, with a result-oriented & problem-solving mindset
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