In this project, you will use advanced 3D imaging and AI-driven cell tracking to reveal the remarkable self-organization of cells within intestinal organoids. Using a biophysics approach, you will study how stem cells move, grow, divide, and differentiate into specific functional cell types, and hence reveal how functional miniature organs are formed. Specifically, you will for the first time reveal how this spatio-temporal program is affected by key molecular signals from the immune system. You will work in a vibrant and supportive team of PhD students and postdocs with physics and biology backgrounds within the Tans and van Zon labs in the AMOLF institute in Amsterdam, and collaborate with leading groups in organoid biology.
We are looking for outstanding experimental physicists, chemists, or biologists with demonstratable interest in quantitative biophysics questions, experience in programming and/or machine learning, handling of complex data, and who thrives in a diverse, collaborative, and supportive environment. Excellent verbal and written English skills are essential.