Research Associate PD/Scale-up Bioconjugates

Research Associate PD/Scale-up Bioconjugates

Lonza

Oss, Netherlands

As a Research Associate PD/ Scale-up Bioconjugates you will operate in a team that supports process development and scale-up of ADC production for early phase collaborations with biotech/pharma companies. The key tasks include; setting up experiments, running reactions and purifying intermediates and final products and interpretation of results. In addition you will characterize the produced ADCs with various analytical tools.

What you’ll do:

• Execution of experiments following established protocols (including but not limited to performing remodeling and bioconjugation experiments, product purification, product fill-finish and product analysis).
• Perform DoE experiments and interpretate the data.
• Perform proof of concept runs (PoC runs).
• Processing, analyzing & documenting of results in ELN.
• Take assigned responsibilities in designated tasks & projects.
• Preparation of production reports and product certificates.
• Provide general support to lab operations.
• Adhere to company policies and quality & safety standards.

What we’re looking for:

• Master of Science (M.Sc.) in a relevant field, preferably in chemical biology, biochemistry, biomedical engineering.
• 1-4 years relevant work experience in Pharma/Biotech area.
• Experience with various protein purification and analysis techniques including TFF, IEX, affinity chromatography (protein A/L, Ni-NTA), SEC, SDS-PAGE, RP-HPLC and MS.
• Experience with handling antibodies, including modification, purification and analysis.
• Familiarity with various bioconjugation chemistry techniques and preferably hands-on experience.
• Strong commitment to laboratory work and project delivery.
• Attention to detail and accuracy.
• Strong team-player mentality.

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