Researcher Therapeutic Protein Engineering at the DDD Platform
Researcher Therapeutic Protein Engineering at the DDD Platform
KTH - Royal Institute of Technology
Solna, Sweden
Job description
The DDD unit "Therapeutic Protein Engineering" (TPE) is attached to KTH and located at SciLifeLab DDD, Solna. The unit's main responsibility is to deliver well-characterized antibodies, antigens, and target proteins to the projects, as well as be technically responsible for the selection-based projects.
Your tasks will be to develop expression and purification protocols for challenging target proteins in our drug discovery projects, as well as to analyze and characterize protein properties such as functionality and conformation using various biochemical and biophysical techniques. Your role will be both lab-based and coordinative.
Qualifications
Requirements
- A doctoral degree or an equivalent foreign degree in biotechnology, biochemistry or molecular biology;
- Thorough experience in cloning, overexpression and purification of proteins in bacteria, insect cells and/or mammalian cells;
- Protein purification using ÄKTA or comparable systems;
- Thorough knowledge of standard protein analysis methods;
- Experience with biophysical protein analysis methods, e.g. ITC, DLS and DSF;
- High level of independence and good collaborative abilities.
Preferred qualifications
- Experience from biotech/pharmaceutical industry or relevant academic research environment;
- Experience with structural biology, especially cryo-EM;
- Experience with SPR;
- Experience with protein engineering;
- Excellent writing and communication skills;
- Project management and coordination;
- Knowledge of diversity and equal opportunity issues, with specific focus on gender equality.
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