Principal Investigator - Molecular Oncology

Principal Investigator - Molecular Oncology

Champalimaud Foundation

Lisbon, Portugal

Offer Description

We are seeking a highly skilled and motivated Principal Investigator with expertise in pancreatic cancer biology, specialising in pancreatic cancer subtyping and tumor heterogeneity. The ideal candidate will have an excellent track-record of publishing high impact papers in pancreatic cancer translational research with an in-depth and working understanding of pancreatic histopathology, cutting-edge analyses including single cell transcriptomics/proteomics and spatial imaging, and the development of in vivo and/or ex vivo model systems.

Duties and responsabilities

Main duties will include

• Lead a dynamic research team focused on molecular oncology for pancreatic cancer, providing scientific direction and mentoring junior staff;
• Design and execute experiments utilising spatial omics approaches to study tumour heterogeneity at the transcriptional, epigenetic and proteomic level in clinically relevant samples;
• Develop and optimise in vivo and/or ex vivo model systems for molecular characterization, validation and manipulation;
• Apply and implement bioinformatic tools to identify, characterize and study different pancreatic cancer cell populations and tissue architectures;
• Collaborate with clinical partners to integrate molecular findings into precision medicine approaches for cancer diagnosis, prognosis, and treatment;
• Stay abreast of advancements in NGS techniques and AI-based imaging technologies, evaluating their potential impact on cancer biology research;
• Publish research findings in high-impact peer-reviewed journals and present results at scientific conferences;
• Contribute to grant writing and fundraising efforts to support ongoing research projects and secure additional funding for future initiatives.

Standards of performance

• Excellent team management, ensuring that staff perform to a high level and that they are appropriately trained and developed in their roles;
• Proactively looking for opportunities to improve service provision and subsequent delivery on the improvements identified;
• All individuals are expected to be flexible in undertaking the duties and responsibilities;
• attached to their job and may be asked to perform other duties which reasonably correspond to the general character of their job and their level of responsibility;
• All individuals are expected to maintain personal and professional development to meet the changing demands of the job and participate in appropriate learning and development activities.

Key relationships

Internal

• Directors of BCPCC;
• Head of Laboratory Operations;
• Health & Safety Officer;
• Laboratory Support Services Manager;
• Facilities manager;
• Research Group Leaders;
• Advanced technology Heads;
• Scientific Researchers;
• IT;
• HR;
• Finance.

External

• International Collaborators;
• Genomics Consortia.

Specific Requirements

Key skills

• Leadership;
• Problem solving;
• Flexibility;
• Attention to detail;
• Communication;
• Organisation;
• Initiative.

Qualifications

• Ph.D. or equivalent degree in biological sciences, molecular medicine, oncology, medical biotechnologies, or a related field;
• Proven track record of research excellence in molecular pathology (at least 3 co-authored high impact factor publications as corresponding or last author), with a focus on pancreatic cancer biology and histology;
• Expertise in bioinformatics analysis of transcriptional, epigenetic and proteomic analysis, including single cell data;
• Experience (hands-on) with histological techniques, laser capture microdissection and histopathological characterisation of pancreatic alteration and malignant transformation;
• Expertise in molecular and cellular biology techniques with advanced knowledge in spatial transcriptomics and imaging;
• Experience in animal handling and surgery, focusing on orthotopic xenotrasplantation of human tissue;
• Experience in managing interdisciplinary studies to develop patient-derived tissue-specific cellular system;
• Strong communication and leadership skills, with the ability to work effectively in a collaborative research environment;
• Demonstrated ability to secure research funding through grants or other mechanisms;
• Prior experience managing research projects and supervising research staff is preferred;
• Excellent level of English.

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Portugal      Biochemistry      Biology      Biomedical and Physiology      Biotechnology and Genetics      Not for Profit      PhD Required      Champalimaud Foundation